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Summary of research on toxic and side effects of turmeric (Research manuscript 2)
2021-10-14 04:58:02 【All thoughts are mountains and seas】
Turmeric grows mainly in South Asia 、 India 、 Indonesia , Its roots and underground stems can be ground into powder and used as seasoning and natural pigment . The kind of turmeric Curcumin The content accounts for about 2-6%
Curcumin like components | The proportion |
Curcumin | 80% |
demethoxycurcumin | 18% |
bisdemethoxycurcumin | 2% |
At present, there are many researchers , Try to improve the bioavailability of curcumin :
( The following passage doesn't look very human , If you don't understand, you can skip , Look at the small conclusions behind these three points .)
1. Nano turmeric
The researchers prepared turmeric in the form of nano colloid , The original particle size is about 22.75um The turmeric powder is reduced to 0.19um, It can improve the solubility 、 And light resistant 、 It's also stable to heat . The researchers put 30mg The nano turmeric is coated in a film made of starch , And match it with 100mL The subjects were given boiling water to ingest , Then blood was drawn to test the content of turmeric in plasma , It is found that the utilization rate of nano turmeric is higher than that of turmeric powder 27 times , About... After ingestion 30 The highest detectable concentration in plasma in minutes , Then it began to fall , It will improve slightly in six hours , Then it plummeted (Ref 6).
2. Turmeric liposome
Turmeric is a fat soluble component , Therefore, the researchers made turmeric into solid lipid turmeric particles , Subjects were asked to ingest separately 650mg Curcuma liposome capsules and 95% Turmeric extract from , Subjects who ingested turmeric liposomes were 2 The peak concentration of curcumin can be detected in plasma after hours , For 22.43 ng/mL, Turmeric could not be detected in the plasma of the group of turmeric extract (Ref 7).
3. Phospholipid complex
Curcumin can hydrogen bond because of its polar group 、 I tried to form a complex with lecithin . Some manufacturers use turmeric extract to 1:2 In proportion to lecithin , In animal experiments, it was found that the absorption rate of this complex was higher than that of general turmeric 20 More than times . In the human experiment, the subjects in the experimental group were divided into 「 Take a low dose 」 And 「 High dose turmeric – Phospholipid complex 」 My experimental group , Take about 209mg as well as 376mg This complex ; And ingestion 1800mg Control group of general curcumin extract . It turns out that , No turmeric was detected in the plasma of the control group , The experimental group detected , In the high-dose group, after ingestion 2 Hours , The concentration in human blood can reach the peak , About 50.3ng/dL, Then it slowly drops . On the whole , The human absorption rate of this product is higher than that of ordinary turmeric 29 times . It is worth noting that , The highest content of curcumin extract detected in human plasma is not curcumin , But another ingredient in turmeric demethoxycurcumin(Ref 8).
So the point of this paragraph is : Daily food is usually only curry with turmeric , Curry dishes are usually cooked with oil , It is a form that is relatively easy to absorb . Natural turmeric contains curcumin , But turmeric is not easily soluble in water, so it is not easy to absorb , And it's easy to metabolize , It is difficult to produce high concentrations in the body . To solve this problem , Scientists used 「 Nanotechnology 」、「 Liposomes 」、「 Phospholipid complex 」 Methods such as , To increase the absorption of turmeric . If you buy a whole piece of turmeric to eat , Or buy a packet of turmeric powder to soak in water , Basically, you can't absorb any curcumin .
Although curcumin has been shown to inhibit many inflammatory cellular pathways and the production of proinflammatory cytokines in cell models , But when applied to human experiments in patients with Alzheimer's disease , It doesn't seem to have a significant effect . This may be related to bioavailability and blood-brain barrier .
● In a study of colorectal cancer ,15 Of the subjects 2 Diarrhea occurred in subjects , The doses given were 0.45mg as well as 3.6mg, One of them continued the experiment after giving antidiarrheal , The other left the experiment . Blood tests found that 4 Subjects developed alkaline phosphatase (alkaline phosphatase) A rising situation ;3 One subject was lactate dehydrogenase (lactate dehydrogenase) More than before the intervention 150%(Ref 10).
In addition to the above two studies , Most of the subjects in the study seemed to have good tolerance to curcumin , Indeed, several studies have shown that a few subjects have gastrointestinal symptoms, including abdominal pain 、 Vomiting, etc , Therefore, the safe dose of curcumin may need more studies to confirm
At the end of last year, the Consumer Foundation gave 19 Plant commercially available turmeric powder for spot check , Two of them were found to have excessive lead content . Therefore, for the magical effect of turmeric, they flocked to buy turmeric powder , Start eating turmeric , Is it possible to eat the benefits of turmeric before , Heavy metal poisoning first ? In terms of products , Of course, there are many curcumin products on the market , The price is per can 1000 Dollar off , The number of capsules per can of each product varies , The curcumin dose of each capsule is not necessarily . Among the above studies, some turmeric comes from specific patented products , Although the results of the research are very good , but As long as there are manufacturers involved , Usually the result is to maintain a relatively high degree of doubt .
The above content comes from 【1】
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また、 Fatty liver disease などの people にウコンを 勧 めないもう One つの reason が、ウコンに contain まれる「 A kind of 」にあると Shallow さんは Words す.
「ウコンのサプリには More quantity の A kind of を contain むものがあります.しかし、 A kind of の Content が Record されていないものがあるのです. A kind of は a の Liver の Well い Fang に Influence を And ぼすことがわかっています.その representative が、C Hepatitis B や Fatty liver disease です. Prevent anemia に Fruit があることで know られる A kind of ですが、 Too many "" で Liver に Accumulate すると、フリーラジカル( Active acid )を He was born させ、 Hepatocytes を Wound つけ、 inflammation を Turn させます. Line dimension (*3)が Enter んで Liver が hard くなるなどして、 The liver is hard や liver がんになる possibility も high まります. private のこれまでの Therapeutic surgery では、 Fatty liver disease の people の blood を Tune べると、ほとんどの people が A kind of が Too long でした.このため、 Fatty liver disease の people はウコンは Limit した Fang がいい. Same as じく A kind of を contain むシジミなども Tongqi です」( Shallow さん)
( Mr. asabu also said , Another reason not to recommend turmeric to fatty liver and others is that turmeric contains “ iron ”.
“ There is more iron in the nutritional supplement food of turmeric . however , There is also no record of iron content . Iron can have adverse effects on some people with poor liver . Its representative is C Hepatitis B and fatty liver . Because it has the effect of preventing anemia, excessive iron intake , If it accumulates in the liver , It produces free radicals ( Reactive oxygen species ), Damage liver cells , Make inflammation worse . Fibrosis (*3) With the deterioration of the liver , The possibility of liver cirrhosis and liver cancer will also increase . In my treatment experience so far , The blood of people with fatty liver was investigated , Most people have excess iron . therefore , It's better to control turmeric for people with fatty liver . There are also clams and shells containing iron ”( Shallow ))
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また、うこん Tea, etc による Cases of liver obstruction も Report されているが、 autumn ウコンの Rhizome は、クルクミン Protoplasm の He にもミネラル branch ( The minute )が Chen Fu に contain まれているものがある. example えばC Patients with chronic hepatitis は、 Have a plan を rise こしやすいことから Make food restriction therapy が Sheshi されるが、そのような Occasion には、うこん contain の The minute が Liver に Too long な Influence を And ばすことがあり、 Be careful が necessary といわれている[37](なお Refined されたクルクミン Protoplasm の Occasion には、 contain ミネラルの The problem is は rise こらない).
( in addition , Although examples of liver dysfunction caused by ginger yellow tea, etc. have also been reported , But the rhizome of autumn Curcuma except curcumin , It's also rich in minerals ( Iron ). for example ,C Patients with chronic hepatitis B are prone to iron excess , So iron restricted diet therapy was implemented , But in this case , The iron component containing turmeric has an excess effect on the liver , We need to pay attention to ( If it's refined curcumin , There will be no problem with minerals ))
The above is from 【4】
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How to make curcumin more easily absorbed in the human body .
Including nano 、 Common intake of pepper
The above is from 【7】
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Reference:
【3】The effect of curcumin (turmeric) on Alzheimer's disease: An overview
【5】 Summary of research on toxic and side effects of turmeric ( Research manuscript 1 )
【6】The effect of curcumin (turmeric) on Alzheimer's disease: An overview
【7】Neuroprotection by curcumin: A review on brain delivery strategies
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The final conclusion ( The side effects of turmeric ):
reason | The result is |
The root contains iron | Hurt the liver |
The turmeric extracted from the market is not hygienic 【1】 | Lead exceeds the standard |
A lot of oxalic acid | It's not good for patients with high uric acid ( Gout ) |
Excessive bile secretion | Gallbladder disease |
Low testosterone levels | Bad for reproduction |
Lower blood sugar | Be careful to faint because of low blood sugar |
Change blood pressure | High blood pressure |
The biggest benefit is naturally to fight Alzheimer's disease 【6】
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本文为[All thoughts are mountains and seas]所创,转载请带上原文链接,感谢
https://chowdera.com/2021/10/20211002145437221j.html
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