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Summary of research on toxic and side effects of turmeric (Research manuscript 2)

2021-10-14 04:58:02 All thoughts are mountains and seas

Turmeric grows mainly in South Asia 、 India 、 Indonesia , Its roots and underground stems can be ground into powder and used as seasoning and natural pigment . The kind of turmeric Curcumin The content accounts for about 2-6%

Curcumin like components The proportion
Curcumin 80%
demethoxycurcumin 18%
bisdemethoxycurcumin 2%

At present, there are many researchers , Try to improve the bioavailability of curcumin :

( The following passage doesn't look very human , If you don't understand, you can skip , Look at the small conclusions behind these three points .)

1. Nano turmeric

The researchers prepared turmeric in the form of nano colloid , The original particle size is about 22.75um The turmeric powder is reduced to 0.19um, It can improve the solubility 、 And light resistant 、 It's also stable to heat . The researchers put 30mg The nano turmeric is coated in a film made of starch , And match it with 100mL The subjects were given boiling water to ingest , Then blood was drawn to test the content of turmeric in plasma , It is found that the utilization rate of nano turmeric is higher than that of turmeric powder 27 times , About... After ingestion 30 The highest detectable concentration in plasma in minutes , Then it began to fall , It will improve slightly in six hours , Then it plummeted (Ref 6).

2. Turmeric liposome

Turmeric is a fat soluble component , Therefore, the researchers made turmeric into solid lipid turmeric particles , Subjects were asked to ingest separately 650mg Curcuma liposome capsules and 95% Turmeric extract from , Subjects who ingested turmeric liposomes were 2 The peak concentration of curcumin can be detected in plasma after hours , For 22.43 ng/mL, Turmeric could not be detected in the plasma of the group of turmeric extract (Ref 7).

3. Phospholipid complex

Curcumin can hydrogen bond because of its polar group 、 I tried to form a complex with lecithin . Some manufacturers use turmeric extract to 1:2 In proportion to lecithin , In animal experiments, it was found that the absorption rate of this complex was higher than that of general turmeric 20 More than times . In the human experiment, the subjects in the experimental group were divided into 「 Take a low dose 」 And 「 High dose turmeric – Phospholipid complex 」 My experimental group , Take about 209mg as well as 376mg This complex ; And ingestion 1800mg Control group of general curcumin extract . It turns out that , No turmeric was detected in the plasma of the control group , The experimental group detected , In the high-dose group, after ingestion 2 Hours , The concentration in human blood can reach the peak , About 50.3ng/dL, Then it slowly drops . On the whole , The human absorption rate of this product is higher than that of ordinary turmeric 29 times . It is worth noting that , The highest content of curcumin extract detected in human plasma is not curcumin , But another ingredient in turmeric demethoxycurcumin(Ref 8).

So the point of this paragraph is : Daily food is usually only curry with turmeric , Curry dishes are usually cooked with oil , It is a form that is relatively easy to absorb . Natural turmeric contains curcumin , But turmeric is not easily soluble in water, so it is not easy to absorb , And it's easy to metabolize , It is difficult to produce high concentrations in the body . To solve this problem , Scientists used 「 Nanotechnology 」、「 Liposomes 」、「 Phospholipid complex 」 Methods such as , To increase the absorption of turmeric . If you buy a whole piece of turmeric to eat , Or buy a packet of turmeric powder to soak in water , Basically, you can't absorb any curcumin .

Although curcumin has been shown to inhibit many inflammatory cellular pathways and the production of proinflammatory cytokines in cell models , But when applied to human experiments in patients with Alzheimer's disease , It doesn't seem to have a significant effect . This may be related to bioavailability and blood-brain barrier .

● In a study of colorectal cancer ,15 Of the subjects 2 Diarrhea occurred in subjects , The doses given were 0.45mg as well as 3.6mg, One of them continued the experiment after giving antidiarrheal , The other left the experiment . Blood tests found that 4 Subjects developed alkaline phosphatase (alkaline phosphatase) A rising situation ;3 One subject was lactate dehydrogenase (lactate dehydrogenase) More than before the intervention 150%(Ref 10).

In addition to the above two studies , Most of the subjects in the study seemed to have good tolerance to curcumin , Indeed, several studies have shown that a few subjects have gastrointestinal symptoms, including abdominal pain 、 Vomiting, etc , Therefore, the safe dose of curcumin may need more studies to confirm

At the end of last year, the Consumer Foundation gave 19 Plant commercially available turmeric powder for spot check , Two of them were found to have excessive lead content . Therefore, for the magical effect of turmeric, they flocked to buy turmeric powder , Start eating turmeric , Is it possible to eat the benefits of turmeric before , Heavy metal poisoning first ? In terms of products , Of course, there are many curcumin products on the market , The price is per can 1000 Dollar off , The number of capsules per can of each product varies , The curcumin dose of each capsule is not necessarily . Among the above studies, some turmeric comes from specific patented products , Although the results of the research are very good , but As long as there are manufacturers involved , Usually the result is to maintain a relatively high degree of doubt .

The above content comes from 【1】

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また、 Fatty liver disease などの people にウコンを 勧 めないもう One つの reason が、ウコンに contain まれる「 A kind of 」にあると Shallow さんは Words す.

 「ウコンのサプリには More quantity の A kind of を contain むものがあります.しかし、 A kind of の Content が Record されていないものがあるのです. A kind of は a の Liver の Well い Fang に Influence を And ぼすことがわかっています.その representative が、C Hepatitis B や Fatty liver disease です. Prevent anemia に Fruit があることで know られる A kind of ですが、 Too many "" で Liver に Accumulate すると、フリーラジカル( Active acid )を He was born させ、 Hepatocytes を Wound つけ、 inflammation を Turn させます. Line dimension (*3)が Enter んで Liver が hard くなるなどして、 The liver is hard や liver がんになる possibility も high まります. private のこれまでの Therapeutic surgery では、 Fatty liver disease の people の blood を Tune べると、ほとんどの people が A kind of が Too long でした.このため、 Fatty liver disease の people はウコンは Limit した Fang がいい. Same as じく A kind of を contain むシジミなども Tongqi です」( Shallow さん)

( Mr. asabu also said , Another reason not to recommend turmeric to fatty liver and others is that turmeric contains “ iron ”.

“ There is more iron in the nutritional supplement food of turmeric . however , There is also no record of iron content . Iron can have adverse effects on some people with poor liver . Its representative is C Hepatitis B and fatty liver . Because it has the effect of preventing anemia, excessive iron intake , If it accumulates in the liver , It produces free radicals ( Reactive oxygen species ), Damage liver cells , Make inflammation worse . Fibrosis (*3) With the deterioration of the liver , The possibility of liver cirrhosis and liver cancer will also increase . In my treatment experience so far , The blood of people with fatty liver was investigated , Most people have excess iron . therefore , It's better to control turmeric for people with fatty liver . There are also clams and shells containing iron ”( Shallow ))

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また、うこん Tea, etc による Cases of liver obstruction も Report されているが、 autumn ウコンの Rhizome は、クルクミン Protoplasm の He にもミネラル branch ( The minute )が Chen Fu に contain まれているものがある. example えばC Patients with chronic hepatitis は、 Have a plan を rise こしやすいことから Make food restriction therapy が Sheshi されるが、そのような Occasion には、うこん contain の The minute が Liver に Too long な Influence を And ばすことがあり、 Be careful が necessary といわれている[37](なお Refined されたクルクミン Protoplasm の Occasion には、 contain ミネラルの The problem is は rise こらない).

( in addition , Although examples of liver dysfunction caused by ginger yellow tea, etc. have also been reported , But the rhizome of autumn Curcuma except curcumin , It's also rich in minerals ( Iron ). for example ,C Patients with chronic hepatitis B are prone to iron excess , So iron restricted diet therapy was implemented , But in this case , The iron component containing turmeric has an excess effect on the liver , We need to pay attention to ( If it's refined curcumin , There will be no problem with minerals ))

The above is from 【4】

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How to make curcumin more easily absorbed in the human body .

Including nano 、 Common intake of pepper

The above is from 【7】

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Reference:

【1】 Turmeric and turmeric powder 17 A complete introduction to possible efficacy and side effects !9 There are physical taboos. Please pay attention to !

【2】【 Alkaline phosphatase 】 The reason of high alkaline phosphatase _ Alkaline phosphatase is low _ Parent child encyclopedia _ Pacific parent-child network

【3】The effect of curcumin (turmeric) on Alzheimer's disease: An overview

【4】クルクミン - japedia.org

【5】 Summary of research on toxic and side effects of turmeric ( Research manuscript 1 )

【6】The effect of curcumin (turmeric) on Alzheimer's disease: An overview

【7】Neuroprotection by curcumin: A review on brain delivery strategies

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The final conclusion ( The side effects of turmeric ):

reason The result is
The root contains iron Hurt the liver
The turmeric extracted from the market is not hygienic 【1】 Lead exceeds the standard
A lot of oxalic acid It's not good for patients with high uric acid ( Gout )
Excessive bile secretion Gallbladder disease
Low testosterone levels Bad for reproduction
Lower blood sugar Be careful to faint because of low blood sugar
Change blood pressure High blood pressure

The biggest benefit is naturally to fight Alzheimer's disease 【6】

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